Publication: Neuro-nutrients as anti-alzheimer's disease agents: A critical review
Issued Date
2019-10-11
Resource Type
ISSN
15497852
10408398
10408398
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2-s2.0-85073624245
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Mahidol University
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SCOPUS
Bibliographic Citation
Critical Reviews in Food Science and Nutrition. Vol.59, No.18 (2019), 2999-3018
Suggested Citation
Sunil K. Ravi, Ramesh B. Narasingappa, Bruno Vincent Neuro-nutrients as anti-alzheimer's disease agents: A critical review. Critical Reviews in Food Science and Nutrition. Vol.59, No.18 (2019), 2999-3018. doi:10.1080/10408398.2018.1481012 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49718
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Title
Neuro-nutrients as anti-alzheimer's disease agents: A critical review
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Abstract
© 2018, © 2018 Taylor & Francis Group, LLC. Alzheimer's disease (AD) is characterized by a massive neuronal death causing memory loss, cognitive impairment and behavioral alteration that ultimately lead to dementia and death. AD is a multi-factorial pathology controlled by molecular events such as oxidative stress, protein aggregation, mitochondrial dysfunction and neuro inflammation. Nowadays, there is no efficient disease-modifying treatment for AD and epidemiological studies have suggested that diet and nutrition have a significant impact on the development of this disorder. Indeed, some nutrients can protect all kind of cells, including neurons. As prevention is better than cure, life style improvement, with a special emphasis on diet, should seriously be considered as an anti-AD track and intake of nutrients promoting neuronal health is the need of the hour. Diets rich in unsaturated fatty acids, polyphenols and vitamins have been shown to protect against AD, whereas saturated fatty acids-containing diets deprived of polyphenols promote the development of the disease. Thus, Mediterranean diets, mainly composed of fruits, vegetables and omega-3 fatty acids, stand as valuable, mild and preventive anti-AD agents. This review focuses on our current knowledge in the field and how one can fight this devastating neurodegenerative disorder through the simple proper modification of our life style.