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Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors

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dc.contributor.authorKoji Matsuokaen_US
dc.contributor.authorChiharu Takitaen_US
dc.contributor.authorTetsuo Koyamaen_US
dc.contributor.authorDaisei Miyamotoen_US
dc.contributor.authorSangchai Yingsakmongkonen_US
dc.contributor.authorKazuya I.P.J. Hidarien_US
dc.contributor.authorWipawee Jampangernen_US
dc.contributor.authorTakashi Suzukien_US
dc.contributor.authorYasuo Suzukien_US
dc.contributor.authorKen Hatanoen_US
dc.contributor.authorDaiyo Terunumaen_US
dc.contributor.otherGraduate School of Science and Engineeringen_US
dc.contributor.otherUniversity of Shizuokaen_US
dc.contributor.otherJapan Science and Technology Agencyen_US
dc.contributor.otherKasetsart Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChubu Universityen_US
dc.date.accessioned2018-08-24T01:41:17Z
dc.date.available2018-08-24T01:41:17Z
dc.date.issued2007-07-15en_US
dc.description.abstractA conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases. © 2007 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationBioorganic and Medicinal Chemistry Letters. Vol.17, No.14 (2007), 3826-3830en_US
dc.identifier.doi10.1016/j.bmcl.2007.05.016en_US
dc.identifier.issn0960894Xen_US
dc.identifier.other2-s2.0-34250351179en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/24163
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34250351179&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleNovel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitorsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34250351179&origin=inwarden_US

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