Generation of human induced pluripotent stem cell line (MUi026-A) from a patient with autosomal dominant polycystic kidney disease carrying PKD1 point mutation
Warun Maneepitasut, Wasinee Wongkummool, Pirut Tong-ngam, Kornkanok Promthep, Alisa Tubsuwan, Aung Khine Linn, Bunyong Phakdeekitcharoen, Suparerk Borwornpinyo, Narisorn Kitiyanant, Phetcharat Phanthong, Suradej Hongeng Generation of human induced pluripotent stem cell line (MUi026-A) from a patient with autosomal dominant polycystic kidney disease carrying PKD1 point mutation. Stem Cell Research. Vol.53, (2021). doi:10.1016/j.scr.2021.102306 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76193
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Generation of human induced pluripotent stem cell line (MUi026-A) from a patient with autosomal dominant polycystic kidney disease carrying PKD1 point mutation
Autosomal dominant polycystic kidney disease (ADPKD) is one of the common genetic kidney disorders that are caused by mutations in PKD1 or PKD2 gene. In this report, the MUi026-A human induced pluripotent stem cell (hiPSC) line was established from the skin fibroblasts of a female ADPKD patient who had the PKD1 mutation with c.5878C > T. The iPSC line retained normal karyotype. The cells displayed embryonic stem cell-like characteristics with pluripotency marker expression and were able to differentiate into three germ layers.
