Publication: Cytochrome c oxidase subunit I haplotype diversity of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae)
Issued Date
2017-07-01
Resource Type
ISSN
18736254
0001706X
0001706X
Other identifier(s)
2-s2.0-85017279949
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Acta Tropica. Vol.171, (2017), 141-145
Suggested Citation
Praphathip Eamsobhana, Sze Looi Song, Hoi Sen Yong, Anchana Prasartvit, Sudarat Boonyong, Anchalee Tungtrongchitr Cytochrome c oxidase subunit I haplotype diversity of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae). Acta Tropica. Vol.171, (2017), 141-145. doi:10.1016/j.actatropica.2017.03.020 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42800
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Cytochrome c oxidase subunit I haplotype diversity of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae)
Other Contributor(s)
Abstract
© 2017 Elsevier B.V. The rat lungworm Angiostrongylus cantonensis is a food-borne zoonotic parasite of public health importance worldwide. It is the primary etiologic agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans in many countries. It is highly endemic in Thailand especially in the northeast region. In this study, A. cantonensis adult worms recovered from the lungs of wild rats in different geographical regions/provinces in Thailand were used to determine their haplotype by means of the mitochondrial partial cytochrome c oxidase subunit I (COI) gene sequence. The results revealed three additional COI haplotypes of A. cantonensis. The geographical isolates of A. cantonensis from Thailand and other countries formed a monophyletic clade distinct from the closely related A. malaysiensis. In the present study, distinct haplotypes were identified in seven regions of Thailand – AC10 in Phitsanulok (northern region), AC11 in Nakhon Phanom (northeastern region), AC15 in Trat (eastern region), AC16 in Chantaburi (eastern region), AC4 in Samut Prakan (central region), AC14 in Kanchanaburi (western region), and AC13 in Ranong (southern region). Phylogenetic analysis revealed that these haplotypes formed distinct lineages. In general, the COI sequences did not differentiate the worldwide geographical isolates of A. cantonensis. This study has further confirmed the presence of COI haplotype diversity in various geographical isolates of A. cantonensis. The COI gene sequence will be a suitable marker for studying population structure, phylogeography and genetic diversity of the rat lungworm.