Publication: A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection.
Issued Date
2008 October
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Language
eng
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application/pdf
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120964 bytes
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Mahidol University
Bibliographic Citation
Nittayananta W, DeRouen TA, Arirachakaran P, Laothumthut T, Pangsomboon K, Petsantad S, et al. A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection. NIH Public Access. 2008;14(7):665-70.
Suggested Citation
W Nittayananta, TA DeRouen, P Arirachakaran, T Laothumthut, K Pangsomboon, S Petsantad, V Vuddhakul, H Sriplung, S Jaruratanasirikul, MD Martin A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection.. Nittayananta W, DeRouen TA, Arirachakaran P, Laothumthut T, Pangsomboon K, Petsantad S, et al. A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection. NIH Public Access. 2008;14(7):665-70.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/1051
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Title
A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection.
Abstract
OBJECTIVE: To determine if chlorhexidine can be used
as an intervention to prolong the time to relapse of oral
candidiasis.
SUBJECTS AND METHODS: A double-blinded randomized
clinical trial was performed in 75 HIV?AIDS subjects
with oral candidiasis. Clotrimazole troche was prescribed,
and the subjects were re-examined every
2 weeks until the lesions were completely eradicated.
The subjects were then randomly divided into two
groups; 0.12% chlorhexidine (n = 37, aged 22–52 years,
mean 34 years) and 0.9% normal saline (n = 38, aged 22–
55 years, mean 38 years). They were re-examined every
2 weeks until the next episode was observed.
RESULTS: The time to recurrence of oral candidiasis
between the chlorhexidine and the saline group was not
statistically significant (P > 0.05). The following variables
were significantly associated with the time of recurrence;
frequency of antifungal therapy (P = 0.011), total lymphocyte
(P = 0.017), alcohol consumption (P = 0.043),
and candidiasis on gingiva (P = 0.048). The subjects with
lower lymphocyte showed shorter oral candidiasis-free periods (P = 0.034).
CONCLUSIONS: Chlorhexidine showed a small but not
statistically significant effect in maintenance of oral candidiasis-
free period. This lack of significance may be
due to the small sample size. Further study should be
performed to better assess the size of the effect, or to confirm our findings.