Publication: Renal Outcomes of Childhood IgA Nephropathy and Henoch Schönlein Purpura Nephritis
Issued Date
2021-01-01
Resource Type
ISSN
22288082
Other identifier(s)
2-s2.0-85116777000
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal. Vol.73, No.10 (2021), 687-694
Suggested Citation
Thanaporn Chaiyapak, Anirut Pattaragarn, Suroj Supavekin, Nuntawan Piyaphanee, Kraisoon Lomjansook, Julaporn Pooliam, Achra Sumboonnanonda Renal Outcomes of Childhood IgA Nephropathy and Henoch Schönlein Purpura Nephritis. Siriraj Medical Journal. Vol.73, No.10 (2021), 687-694. doi:10.33192/Smj.2021.88 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78592
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Renal Outcomes of Childhood IgA Nephropathy and Henoch Schönlein Purpura Nephritis
Other Contributor(s)
Abstract
Objective: Henoch-Schonlein purpura nephritis (HSPN) is considered the systemic form of IgA nephropathy (IgAN). However, differing clinicopathological features and renal outcomes of children with IgAN and HSPN have been reported in some studies. Materials and Methods: This study retrospectively reviewed children with IgAN and HSPN younger than 18 years, between January 2004 and December 2015. The clinicopathological characteristics at diagnosis and the renal outcomes after at least 1 year of follow-up were compared between the two groups. Results: A total of 54 children, comprising 21 with IgAN and 33 with HSPN, were recruited. The children with HSPN were younger than the children with IgAN. Gross hematuria and nephritic syndrome at the initial presentation were more common in children with IgAN. Regarding the pathological findings, IgAN had greater chronicity than HSPN. After a median follow-up period from first presentation to renal outcomes measurement of 4.0 years (1.312.2) in children with IgAN and 4.2 years (1.1-11.4) in children with HSPN, the renal outcomes were better in the latter group. The incidence of chronic kidney disease (CKD) was 28.6% in children with IgAN and 6.1% in children with HSPN (p = 0.02). Complete recovery was observed more frequently in children with HSPN than in children with IgAN (57.1% in IgAN vs. 87.9% in HSPN, p = 0.01). Conclusion: Childhood IgAN has greater chronicity and worse renal outcomes than childhood HSPN, with a lower rate of complete recovery and a higher frequency of CKD. We recommend long-term follow-up for CKD in children with IgAN.