Publication: Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L.
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Issued Date
1992-01-01
Resource Type
ISSN
10982280
08936692
08936692
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2-s2.0-0026480572
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Mahidol University
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SCOPUS
Bibliographic Citation
Environmental and Molecular Mutagenesis. Vol.20, No.4 (1992), 307-312
Suggested Citation
Malyn Chulasiri, Nuntawan Bunyapraphatsara, Primchanien Moongkarndi Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L.. Environmental and Molecular Mutagenesis. Vol.20, No.4 (1992), 307-312. doi:10.1002/em.2850200409 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22288
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Title
Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L.
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Abstract
Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 μg/plate, both compounds showed no mutagenicity and no cytotoxicity toward S. typhimurium strains TA98 and TA100 either in the presence or absence of S9 mix. However, these substances were antimutagens toward 2–aminoanthracene, aflatoxin Bl (in TA98), and dimethylnitrosamine (in TA100); but neither substance inhibited the direct mutagenic activity of 2‐(2‐furyl)‐3‐(5‐nitro‐2‐furyl) acrylamide nor that of sodium azide in strains TA98 and TA100, respectively. © 1992 Wiley‐Liss, Inc. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company