Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue
Koen Van Besien, Claire Verschraegen, Rakesh Mehra, Sergio Giralt, Andrzej P. Kudelka, Creighton L. Edwards, Surintip Piamsonboom, Wichai Termrungruanglert, Richard Champlin, John J. Kavanagh Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue. Gynecologic Oncology. Vol.65, No.2 (1997), 366-369. doi:10.1006/gyno.1997.4677 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18213
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue
Patients with chemotherapy-refractory gestational trophoblastic disease and brain metastasis are considered to have a very poor prognosis. We present the case of a patient who had failed several chemotherapeutic regimens. Despite transient responses to chemotherapy, she had not achieved a complete remission in 3 years, and had developed systemic disease and recurrent brain metastasis. She was treated with four cycles of high-dose ifosfamide, carboplatin, and etoposide with blood progenitor cell support. She tolerated this regimen well and has obtained a complete remission that is ongoing for 12 months.
