Publication:
Long-term loss to follow-up in the TREAT Asia HIV Observational Database (TAHOD)

Issued Date

2019-08-01

Resource Type

Article

ISSN

14681293
14642662

DOI

10.1111/hiv.12734

Other identifier(s)

2-s2.0-85064480879

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

HIV Medicine. Vol.20, No.7 (2019), 439-449

Suggested Citation

A. Jiamsakul, S. Kiertiburanakul, O. T. Ng, R. Chaiwarith, W. Wong, R. Ditangco, K. V. Nguyen, A. Avihingsanon, S. Pujari, C. D. Do, M. P. Lee, P. S. Ly, E. Yunihastuti, N. Kumarasamy, A. Kamarulzaman, J. Tanuma, F. Zhang, J. Y. Choi, P. Kantipong, B. L.H. Sim, J. Ross, M. Law, T. P. Merati, P. S. Ly, V. Khol, F. J. Zhang, H. X. Zhao, N. Han, M. P. Lee, P. C.K. Li, W. Lam, Y. T. Chan, N. Kumarasamy, S. Saghayam, C. Ezhilarasi, S. Pujari, K. Joshi, S. Gaikwad, A. Chitalikar, S. Sangle, V. Mave, I. Marbaniang, T. P. Merati, D. N. Wirawan, F. Yuliana, E. Yunihastuti, D. Imran, A. Widhani, J. Tanuma, S. Oka, T. Nishijima, J. Y. Choi, S. Na, J. M. Kim, B. L.H. Sim, Y. M. Gani, N. B. Rudi, A. Kamarulzaman, S. F. Syed Omar, S. Ponnampalavanar, I. Azwa, R. Ditangco, M. K. Pasayan, M. L. Mationg, W. W. Wong, W. W. Ku, P. C. Wu, O. T. Ng, P. L. Lim, L. S. Lee, Z. Ferdous, A. vihingsanon, S. Gatechompol, P. Phanuphak, C. Phadungphon, S. Kiertiburanakul, A. Phuphuakrat, L. Chumla, N. Sanmeema, R. Chaiwarith, T. Sirisanthana, W. Kotarathititum, J. Praparattanapan, S. Khusuwan, K. V. Nguyen, H. V. Bui, D. T.H. Nguyen, D. T. Nguyen, C. D. Do, A. V. Ngo, L. T. Nguyen, A. H. Sohn, L. Ross, B. Petersen, M. G. Law, D. Rupasinghe Long-term loss to follow-up in the TREAT Asia HIV Observational Database (TAHOD). HIV Medicine. Vol.20, No.7 (2019), 439-449. doi:10.1111/hiv.12734 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51522

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Title

Long-term loss to follow-up in the TREAT Asia HIV Observational Database (TAHOD)

Author(s)

A. Jiamsakul
 S. Kiertiburanakul
 O. T. Ng
 R. Chaiwarith
 W. Wong
 R. Ditangco
 K. V. Nguyen
 A. Avihingsanon
 S. Pujari
 C. D. Do
 M. P. Lee
 P. S. Ly
 E. Yunihastuti
 N. Kumarasamy
 A. Kamarulzaman
 J. Tanuma
 F. Zhang
 J. Y. Choi
 P. Kantipong
 B. L.H. Sim
 J. Ross
 M. Law
 T. P. Merati
 P. S. Ly
 V. Khol
 F. J. Zhang
 H. X. Zhao
 N. Han
 M. P. Lee
 P. C.K. Li
 W. Lam
 Y. T. Chan
 N. Kumarasamy
 S. Saghayam
 C. Ezhilarasi
 S. Pujari
 K. Joshi
 S. Gaikwad
 A. Chitalikar
 S. Sangle
 V. Mave
 I. Marbaniang
 T. P. Merati
 D. N. Wirawan
 F. Yuliana
 E. Yunihastuti
 D. Imran
 A. Widhani
 J. Tanuma
 S. Oka
 T. Nishijima
 J. Y. Choi
 S. Na
 J. M. Kim
 B. L.H. Sim
 Y. M. Gani
 N. B. Rudi
 A. Kamarulzaman
 S. F. Syed Omar
 S. Ponnampalavanar
 I. Azwa
 R. Ditangco
 M. K. Pasayan
 M. L. Mationg
 W. W. Wong
 W. W. Ku
 P. C. Wu
 O. T. Ng
 P. L. Lim
 L. S. Lee
 Z. Ferdous
 A. vihingsanon
 S. Gatechompol
 P. Phanuphak
 C. Phadungphon
 S. Kiertiburanakul
 A. Phuphuakrat
 L. Chumla
 N. Sanmeema
 R. Chaiwarith
 T. Sirisanthana
 W. Kotarathititum
 J. Praparattanapan
 S. Khusuwan
 K. V. Nguyen
 H. V. Bui
 D. T.H. Nguyen
 D. T. Nguyen
 C. D. Do
 A. V. Ngo
 L. T. Nguyen
 A. H. Sohn
 L. Ross
 B. Petersen
 M. G. Law
 D. Rupasinghe

Other Contributor(s)

The Voluntary Health Services, Chennai
 Hospital Sungai Buloh
 Beijing Ditan Hospital Capital Medical University
 Gokila
 Bach Mai Hospital
 Universitas Udayana
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Chulalongkorn University
 Kirby Institute
 National Center for Global Health and Medicine
 Yonsei University College of Medicine
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Queen Elizabeth Hospital Hong Kong
 University of Malaya Medical Centre
 Veterans General Hospital-Taipei
 Tan Tock Seng Hospital
 Chiang Mai University
 University of Health Sciences
 National Hospital for Tropical Diseases
 Foundation for AIDS Research
 Institute of Infectious Diseases
 Chiangrai Prachanukroh Hospital

Abstract

© 2019 British HIV Association Objectives: With earlier antiretroviral therapy (ART) initiation, time spent in HIV care is expected to increase. We aimed to investigate loss to follow-up (LTFU) in Asian patients who remained in care 5 years after ART initiation. Methods: Long-term LTFU was defined as LTFU occurring after 5 years on ART. LTFU was defined as (1) patients not seen in the previous 12 months; and (2) patients not seen in the previous 6 months. Factors associated with LTFU were analysed using competing risk regression. Results: Under the 12-month definition, the LTFU rate was 2.0 per 100 person-years (PY) [95% confidence interval (CI) 1.8–2.2 among 4889 patients included in the study. LTFU was associated with age > 50 years [sub-hazard ratio (SHR) 1.64; 95% CI 1.17–2.31] compared with 31–40 years, viral load ≥ 1000 copies/mL (SHR 1.86; 95% CI 1.16–2.97) compared with viral load < 1000 copies/mL, and hepatitis C coinfection (SHR 1.48; 95% CI 1.06–2.05). LTFU was less likely to occur in females, in individuals with higher CD4 counts, in those with self-reported adherence ≥ 95%, and in those living in high-income countries. The 6-month LTFU definition produced an incidence rate of 3.2 per 100 PY (95% CI 2.9–3.4 and had similar associations but with greater risks of LTFU for ART initiation in later years (2006–2009: SHR 2.38; 95% CI 1.93–2.94; and 2010–2011: SHR 4.26; 95% CI 3.17–5.73) compared with 2003–2005. Conclusions: The long-term LTFU rate in our cohort was low, with older age being associated with LTFU. The increased risk of LTFU with later years of ART initiation in the 6-month analysis, but not the 12-month analysis, implies that there was a possible move towards longer HIV clinic scheduling in Asia.

Keyword(s)

Medicine

Availability

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https://repository.li.mahidol.ac.th/handle/20.500.14594/51522

Collections

Scopus 2019