Publication: Promotion of Rat Hepatocarcinogenesis by Praziquantel
Issued Date
1991-01-01
Resource Type
ISSN
13497006
09105050
09105050
Other identifier(s)
2-s2.0-0026002901
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Mahidol University
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SCOPUS
Bibliographic Citation
Japanese Journal of Cancer Research. Vol.82, No.10 (1991), 1085-1088
Suggested Citation
Tomoyuki Shirai, Kim Dae Joong, Kazuo Hakoi, Witaya Thamavit, Chawalit Pairojkul, Toru Hoshiya, Ryohei Hasegawa, Nobuyuki Ito Promotion of Rat Hepatocarcinogenesis by Praziquantel. Japanese Journal of Cancer Research. Vol.82, No.10 (1991), 1085-1088. doi:10.1111/j.1349-7006.1991.tb01761.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22010
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Title
Promotion of Rat Hepatocarcinogenesis by Praziquantel
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Abstract
Praziquantel, the widely used anti‐helminthic agent, was investigated for hepatocarcinogenesis‐promoting potential using a medium‐term liver bioassay system for carcinogens. F344 male rats were given a single intraperitoneal injection of diethylnitrosamine (DEN, 200 mg/kg) and then starting 2 weeks later, received praziquantel in the diet at concentrations of 1.5 or 0.5%, or intragastrically at a dose of 1,500 mg/kg once a week for 6 weeks. Control groups received DEN or praziquantel alone. All rats were subjected to two‐thirds partial hepatectomy at week 3 and killed at week 8. Development of glutathione 5‐transferase placental form‐positive foci in the liver was significantly increased in terms of both number and area with the 1.5% dose, while only area was affected by the 0.5% dose. The results thus indicate that praziquantel at high dose has promoting potential in rat hepatocytic tumorigenesis. Copyright © 1991, Wiley Blackwell. All rights reserved