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Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1

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dc.contributor.authorCarlota Piresen_US
dc.contributor.authorBenjamin Schmiden_US
dc.contributor.authorCarina Petræusen_US
dc.contributor.authorAnna Poonen_US
dc.contributor.authorNatakarn Nimsanoren_US
dc.contributor.authorTroels T. Nielsenen_US
dc.contributor.authorGunhild Waldemaren_US
dc.contributor.authorLena E. Hjerminden_US
dc.contributor.authorJørgen E. Nielsenen_US
dc.contributor.authorPoul Hyttelen_US
dc.contributor.authorKristine K. Freudeen_US
dc.contributor.otherKøbenhavns Universiteten_US
dc.contributor.otherBioneer ASen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-12-11T02:09:52Z
dc.date.accessioned2019-03-14T08:03:59Z
dc.date.available2018-12-11T02:09:52Z
dc.date.available2019-03-14T08:03:59Z
dc.date.issued2016-09-01en_US
dc.description.abstract© 2016 Helmholtz Zentrum München Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease causing neural cell degeneration and brain atrophy and is considered to be the most common form of dementia. We previously generated an induced pluripotent stem cell (iPSC) line from an AD patient carrying an A79V mutation in PSEN1 as an in vitro disease model. Here we generated a gene-corrected version from this hiPSC line by substituting the point mutation with the wild-type sequence. The reported A79V-GC-iPSCs line is a very useful resource in combination with the A79V-iPSC line in order to study pathological cellular phenotypes related to this particular mutation.en_US
dc.identifier.citationStem Cell Research. Vol.17, No.2 (2016), 285-288en_US
dc.identifier.doi10.1016/j.scr.2016.08.002en_US
dc.identifier.issn18767753en_US
dc.identifier.issn18735061en_US
dc.identifier.other2-s2.0-85028072813en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/42941
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85028072813&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleGeneration of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85028072813&origin=inwarden_US

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