Publication: Functional variation of HIV-1 Rev Response Element in a longitudinally studied cohort
Issued Date
2005-03-01
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ISSN
01466615
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2-s2.0-12944265407
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Medical Virology. Vol.75, No.3 (2005), 367-373
Suggested Citation
Angsana Phuphuakrat, Robert M. Paris, Sorachai Nittayaphan, Suda Louisirirotchanakul, Prasert Auewarakul Functional variation of HIV-1 Rev Response Element in a longitudinally studied cohort. Journal of Medical Virology. Vol.75, No.3 (2005), 367-373. doi:10.1002/jmv.20279 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16605
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Title
Functional variation of HIV-1 Rev Response Element in a longitudinally studied cohort
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Abstract
We showed previously that HIV-1 Rev Response Element (RRE) contains a certain degree of structural variation, and in a set of limited samples, RRE from HIV-1 natural isolates were found to have functional variability. The significance of the RRE heterogeneity is addressed further by analyzing the functional variation of RREs in a longitudinal cohort. While the RRE activity at early time points was not a good predictor of disease outcome, the RRE activity at late time points was correlated with rates of CD4+ count decline. These data suggest that RRE heterogeneity may be important in viral pathogenesis and disease progression. © 2005 Wiley-Liss, Inc.
