Publication: A bioactive triterpenoid and vulpinic acid derivatives from the mushroom Scleroderma citrinum
| dc.contributor.author | Somdej Kanokmedhakul | en_US |
| dc.contributor.author | Kwanjai Kanokmedhakul | en_US |
| dc.contributor.author | Thirada Prajuabsuk | en_US |
| dc.contributor.author | Kasem Soytong | en_US |
| dc.contributor.author | Palangpon Kongsaeree | en_US |
| dc.contributor.author | Apichart Suksamrarn | en_US |
| dc.contributor.other | Khon Kaen University | en_US |
| dc.contributor.other | King Mongkut's Institute of Technology Ladkrabang | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Ramkhamhaeng University | en_US |
| dc.date.accessioned | 2018-07-24T03:19:48Z | |
| dc.date.available | 2018-07-24T03:19:48Z | |
| dc.date.issued | 2003-06-01 | en_US |
| dc.description.abstract | A new lanostane-type triterpenoid, (20S,22S,23E)-22-O-acetyl-25-hydroxylanosta-8,23(E)-dien-3-one (1), isolated as a new natural product for the first time, methyl 4,4′-dimethoxyvulpinate (2), together with the known compound 4,4′-dimethoxyvulpinic acid (3) were isolated from the mushroom Scleroderma citrinum. Their structures were determined using spectroscopic and chemical methods, and an X-ray analysis was performed to confirm structure of 1. Compound 1 exhibited significant antiviral activity against Herpes simplex type 1. Compound 3 and two of its derivatives, the dibromo derivative 5 and acetate derivative 6, exhibited activity towards Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the NCI-H187 cell line. | en_US |
| dc.identifier.citation | Planta Medica. Vol.69, No.6 (2003), 568-571 | en_US |
| dc.identifier.doi | 10.1055/s-2003-40639 | en_US |
| dc.identifier.issn | 00320943 | en_US |
| dc.identifier.other | 2-s2.0-0037488435 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/20723 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037488435&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | A bioactive triterpenoid and vulpinic acid derivatives from the mushroom Scleroderma citrinum | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037488435&origin=inward | en_US |