Publication:
High burden of cerebral white matter lesion in 9 Asian cities

Issued Date

2021-12-01

Resource Type

Article

ISSN

20452322

DOI

10.1038/s41598-021-90746-x

Other identifier(s)

2-s2.0-85107213249

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Scientific Reports. Vol.11, No.1 (2021)

Suggested Citation

Bonnie Yin Ka Lam, Brian Yiu, Encarnita Ampil, Christopher Li Hsian Chen, Yustiani Dikot, Jacqueline C. Dominguez, Patel Vishal Ganeshbhai, Saima Hilal, Nagaendran Kandiah, Sang Yun Kim, Jun Young Lee, Anam Paulus Ong, Vorapun Senanarong, Kam Tat Leung, Huali Wang, Yuan Han Yang, Tingting Yong, Faheem Arshad, Suvarna Alladi, Samuel Wong, Ho Ko, Alexander Yuk Lun Lau, Vincent Chung Tong Mok High burden of cerebral white matter lesion in 9 Asian cities. Scientific Reports. Vol.11, No.1 (2021). doi:10.1038/s41598-021-90746-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/79243

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Title

High burden of cerebral white matter lesion in 9 Asian cities

Author(s)

Bonnie Yin Ka Lam
 Brian Yiu
 Encarnita Ampil
 Christopher Li Hsian Chen
 Yustiani Dikot
 Jacqueline C. Dominguez
 Patel Vishal Ganeshbhai
 Saima Hilal
 Nagaendran Kandiah
 Sang Yun Kim
 Jun Young Lee
 Anam Paulus Ong
 Vorapun Senanarong
 Kam Tat Leung
 Huali Wang
 Yuan Han Yang
 Tingting Yong
 Faheem Arshad
 Suvarna Alladi
 Samuel Wong
 Ho Ko
 Alexander Yuk Lun Lau
 Vincent Chung Tong Mok

Other Contributor(s)

Peking University Sixth Hospital
 National University Health System
 Seoul National University Bundang Hospital
 Chinese University of Hong Kong, Faculty of Medicine
 Kaohsiung Medical University Chung-Ho Memorial Hospital
 University of Santo Tomas, Manila
 Hasan Sadikin Hospital
 National Neuroscience Institute of Singapore
 National University of Singapore
 National Institute of Mental Health and Neuro Sciences
 Mahidol University
 Chinese University of Hong Kong
 Seoul National University College of Medicine
 Jenderal Achmad Yani University
 St. Luke's Medical Centre

Abstract

Age-related white matter lesion (WML) is considered a manifestation of sporadic cerebral small vessel disease and an important pathological substrate for dementia. Asia is notable for its large population with a looming dementia epidemic. Yet, the burden of WML and its associated risk factors across different Asian societies are unknown. Subjects from 9 Asian cities (Bangkok, Bandung, Beijing, Bengaluru, Hong Kong, Kaohsiung, Manila, Seoul, and Singapore) were recruited (n = 5701) and classified into (i) stroke/transient ischemic attack (TIA), (ii) Alzheimer’s disease (AD)/mild cognitive impairment (MCI), or (iii) control groups. Data on vascular risk factors and cognitive performance were collected. The severity of WML was visually rated on MRI or CT. The prevalence of moderate-to-severe WML was the highest in subjects with stroke/TIA (43.3%). Bandung Indonesia showed the highest prevalence of WML, adjusted for age, sex, education, disease groups, and imaging modality. Hypertension and hyperlipidemia were significant risk factors for WML, and WML was negatively associated with MMSE in all groups. WML is highly prevalent in Asia and is associated with increasing age, hypertension, hyperlipidemia, and worse cognitive performance. Concerted efforts to prevent WML will alleviate the huge dementia burden in the rapidly aging Asian societies.

Keyword(s)

Multidisciplinary

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/79243

Collections

Scopus 2021