Publication: Efficacy of fluocinolone acetonide gel in the treatment of oral lichen planus.
Issued Date
2000-01-01
Resource Type
ISSN
10792104
Other identifier(s)
2-s2.0-0033627875
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Mahidol University
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SCOPUS
Bibliographic Citation
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. Vol.89, No.1 (2000), 42-45
Suggested Citation
Waranun Buajeeb, Chongdee Pobrurksa, Petcharat Kraivaphan Efficacy of fluocinolone acetonide gel in the treatment of oral lichen planus.. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. Vol.89, No.1 (2000), 42-45. doi:10.1016/S1079-2104(00)80012-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25926
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Title
Efficacy of fluocinolone acetonide gel in the treatment of oral lichen planus.
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Abstract
OBJECTIVE: The purpose of this study was to compare the efficacy of fluocinolone acetonide gel 0.1% in 2 base forms (numbers 1 and 2) with fluocinolone acetonide in an oral base 0.1%. STUDY DESIGN: Forty-eight patients with histologically confirmed oral lichen planus were enrolled in the study. Lesions were scored ranging from 0 (no lesion) to 5 (large erosion) according to the severity. Patients were randomly given fluocinolone acetonide in an oral base, fluocinolone acetonide gel no. 1 or no. 2. They were asked to apply the medication on dried lesions 4 times a day. The lesions were evaluated after 2 and 4 weeks of treatment. The severity scores were analyzed by the Kruskal-Wallis k-sample test. RESULTS: Patients who received fluocinolone acetonide in an oral base and those who received fluocinolone acetonide gel no. 1 and no. 2 improved from the average score of 3.0, 3.0, and 2.9 to 1.5, 1.5, and 1.6, respectively. There were no statistically significant differences in score changes noted in the 3 groups. The results indicate that fluocinolone acetonide gel no. 1 and no. 2 and fluocinolone acetonide in an oral base provide similar efficacy in the treatment of oral lichen planus. CONCLUSION: Fluocinolone acetonide gel 0.1% is a safe and effective alternative therapy to fluocinolone acetonide in an oral base 0.1% in the treatment of oral lichen planus.