Publication: Meta-analysis of cytokine gene polymorphisms and outcome of heart transplantation
Issued Date
2013-09-23
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ISSN
23146141
23146133
23146133
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2-s2.0-84884234521
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Mahidol University
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SCOPUS
Bibliographic Citation
BioMed Research International. Vol.2013, (2013)
Suggested Citation
Sasitorn Yongcharoen, Sasivimol Rattanasiri, D. Olga McDaniel, Mark McEvoy, Chukiat Viwatwongkaseam, Piangchan Rojanavipart, Ammarin Thakkinstian Meta-analysis of cytokine gene polymorphisms and outcome of heart transplantation. BioMed Research International. Vol.2013, (2013). doi:10.1155/2013/387184 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31213
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Title
Meta-analysis of cytokine gene polymorphisms and outcome of heart transplantation
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Abstract
We performed a systematic review and meta-analysis with the aim of assessing the association between cytokine gene polymorphisms and graft rejection in heart transplantation. We identified relevant studies from Medline and Embase using PubMed and Ovid search engines, respectively. Allele frequencies and allele and genotypic effects were pooled. Heterogeneity and publication bias were explored. Four to 5 studies were included in pooling of 3 gene polymorphisms. The prevalences of the minor alleles for TNFα-308, TGFβ1-c10, and TGFβ1-c25 were 0.166 (95% CI: 0.129, 0.203), 0.413 (95% CI: 0.363, 0.462), and 0.082 (95% CI: 0.054, 0.111) in the control groups, respectively. Carrying the A allele for the TNFα-308 had 18% (95% CI of OR: 0.46, 3.01) increased risk, but this was not significant for developing graft rejection than the G allele. Conversely, carrying the minor alleles for both TGFβ1-c10 and c25 had nonsignificantly lower odds of graft rejection than major alleles, with the pooled ORs of 0.87 (95% CI: 0.65, 1.18) and 0.70 (95% CI: 0.40, 1.23), respectively. There was no evidence of publication bias for all poolings. An updated meta-analysis is required when more studies are published to increase the power of detection for the association between these polymorphisms and allograft rejection. © 2013 Sasitorn Yongcharoen et al.