Publication:
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.

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tm-ar-kesinee-2014.pdf (2.24 MB)

Accepted Date

2014-10-29

Issued Date

2014-12-09

Copyright Date

2014

Resource Type

Article

Language

eng

ISSN

1475-2875 (electronic)

DOI

10.1186/1475-2875-13-483.

Rights

Mahidol University

Rights Holder(s)

BioMed Central

Bibliographic Citation

White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, et al. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014 Dec 9;13:483.

Suggested Citation

White, Nicholas J, Ashley, Elizabeth A, Recht, Judith, Delves, Michael J, Ruecker, Andrea, Smithuis, Frank M, Eziefula, Alice C, Bousema, Teun, Drakeley, Chris, Kesinee Chotivanich, เกศินี โชติวานิช, Mallika Imwong, มัลลิกา อิ่มวงศ์, Sasithon Pukrittayakamee, ศศิธร ผู้กฤตยาคามี, Jetsumon Prachumsri, เจตสุมน ประจำศรี, Chu, Cindy, Andolina, Chiara, Bancone, Germana, Hien, Tran T, Mayxay, Mayfong, Taylor, Walter RJ, Seidlein, Lorenz von, Price, Ric N, Barnes, Karen I, Djimdé, Abdoulaye, ter Kuile, Feiko, Gosling, Roly, Chen, Ingrid, Dhorda, Mehul J, Stepniewska, Kasia, Guérin, Philippe, Woodrow, Charles J, Dondorp, Arjen M, Day, Nicholas PJ, Nosten, Francois H Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.. White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, et al. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014 Dec 9;13:483.. doi:10.1186/1475-2875-13-483. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/843

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Title

Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.

Author(s)

White, Nicholas J
 Ashley, Elizabeth A
 Recht, Judith
 Delves, Michael J
 Ruecker, Andrea
 Smithuis, Frank M
 Eziefula, Alice C
 Bousema, Teun
 Drakeley, Chris
 Kesinee Chotivanich
 เกศินี โชติวานิช
 Mallika Imwong
 มัลลิกา อิ่มวงศ์
 Sasithon Pukrittayakamee
 ศศิธร ผู้กฤตยาคามี
 Jetsumon Prachumsri
 เจตสุมน ประจำศรี
 Chu, Cindy
 Andolina, Chiara
 Bancone, Germana
 Hien, Tran T
 Mayxay, Mayfong
 Taylor, Walter RJ
 Seidlein, Lorenz von
 Price, Ric N
 Barnes, Karen I
 Djimdé, Abdoulaye
 ter Kuile, Feiko
 Gosling, Roly
 Chen, Ingrid
 Dhorda, Mehul J
 Stepniewska, Kasia
 Guérin, Philippe
 Woodrow, Charles J
 Dondorp, Arjen M
 Day, Nicholas PJ
 Nosten, Francois H

Corresponding Author(s)

White, Nicholas J

Other Contributor(s)

Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.
 Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.
 Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.
 Mahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unit.
 Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.

Abstract

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

Keyword(s)

Drugs
 Gametocytocidal
 Malaria
 Plasmodium falciparum
 Therapeutic
 Open Access article

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/843

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TM-Article