Narong Sarisuta, Tassanee Thamsakdakorn, Somboon Jateteela Effects of temperature and humidity on the physical properties of piroxicam tablets. Pharmaceutical Technology. Vol.23, No.4 (1999). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25342
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Effects of temperature and humidity on the physical properties of piroxicam tablets
The authors studied piroxicam tablets containing various proportions of filler (lactose or mannitol) after storage for 12 weeks of 40 °C and 52% relative humidity (RH) and at 40°C and 96% RH. The tablets were prepared by wet granulation using providone as a binder. They were compressed at forces of 500-600 kg for hardness values of 6-7 kg and stored in a controlled environmental chamber. Physical properties of the tablets such as weight, thickness, hardness, loss on drying, disintegration, and dissolution were assessed every 2 weeks. This article discusses the methods used to conduct the studies and the results.
