Publication: Reduced interleukin-17 expression of Burkholderia pseudomallei-infected peripheral blood mononuclear cells of diabetic patients
Issued Date
2008-03-01
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ISSN
0125877X
Other identifier(s)
2-s2.0-45349087840
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.26, No.1 (2008), 63-69
Suggested Citation
Sutatip Pongcharoen, Pannika Niumsup Ritvirool, Donruedee Sanguansermsri, Pairat Chanchan, Poj Jienmongkol, Puntharee Butkhamchot, Prateep Warnnissorn, Napatawn Banchuin, Stitaya Sirisinha Reduced interleukin-17 expression of Burkholderia pseudomallei-infected peripheral blood mononuclear cells of diabetic patients. Asian Pacific Journal of Allergy and Immunology. Vol.26, No.1 (2008), 63-69. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19753
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Title
Reduced interleukin-17 expression of Burkholderia pseudomallei-infected peripheral blood mononuclear cells of diabetic patients
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Abstract
Burkholderia pseudomallei is the causative agent of melioidosis. One of the main risk factors for B. pseudomallei infection in endemic areas is diabetes mellitus. The present study investigated IL-17 mRNA and protein expression by peripheral blood mononuclear cells in response to B. pseudomallei infection in 10 diabetic patients in comparison to 10 healthy blood donors. The IL-17 expression in diabetic patients was significantly lower (p<0.05) than in the controls. However, IL-23 mRNA expression of the 2 groups was comparable. The present findings suggest that melioidosis affects T cell IL-17 production and that patients with diabetes mellitus have a defective IL-17 production in response to this type of infection.