Publication:
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Issued Date

2016-12-12

Resource Type

Article

ISSN

18783686
15356108

DOI

10.1016/j.ccell.2016.11.003

Other identifier(s)

2-s2.0-85004009880

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Cancer Cell. Vol.30, No.6 (2016), 891-908

Suggested Citation

Jonathon Torchia, Brian Golbourn, Shengrui Feng, King Ching Ho, Patrick Sin-Chan, Alexandre Vasiljevic, Joseph D. Norman, Paul Guilhamon, Livia Garzia, Natalia R. Agamez, Mei Lu, Tiffany S. Chan, Daniel Picard, Pasqualino de Antonellis, Dong Anh Khuong-Quang, Aline C. Planello, Constanze Zeller, Dalia Barsyte-Lovejoy, Lucie Lafay-Cousin, Louis Letourneau, Mathieu Bourgey, Man Yu, Deena M.A. Gendoo, Misko Dzamba, Mark Barszczyk, Tiago Medina, Alexandra N. Riemenschneider, A. Sorana Morrissy, Young Shin Ra, Vijay Ramaswamy, Marc Remke, Christopher P. Dunham, Stephen Yip, Ho keung Ng, Jian Qiang Lu, Vivek Mehta, Steffen Albrecht, Jose Pimentel, Jennifer A. Chan, Gino R. Somers, Claudia C. Faria, Lucia Roque, Maryam Fouladi, Lindsey M. Hoffman, Andrew S. Moore, Yin Wang, Seung Ah Choi, Jordan R. Hansford, Daniel Catchpoole, Diane K. Birks, Nicholas K. Foreman, Doug Strother, Almos Klekner, Laszló Bognár, Miklós Garami, Péter Hauser, Tibor Hortobágyi, Beverly Wilson, Juliette Hukin, Anne Sophie Carret, Timothy E. Van Meter, Eugene I. Hwang, Amar Gajjar, Shih Hwa Chiou, Hideo Nakamura, Helen Toledano, Iris Fried, Daniel Fults, Takafumi Wataya, Chris Fryer, David D. Eisenstat, Katrin Scheinemann, Adam J. Fleming, Donna L. Johnston, Jean Michaud Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell. Vol.30, No.6 (2016), 891-908. doi:10.1016/j.ccell.2016.11.003 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42259

Research Projects

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Thesis

Title

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Author(s)

Jonathon Torchia
 Brian Golbourn
 Shengrui Feng
 King Ching Ho
 Patrick Sin-Chan
 Alexandre Vasiljevic
 Joseph D. Norman
 Paul Guilhamon
 Livia Garzia
 Natalia R. Agamez
 Mei Lu
 Tiffany S. Chan
 Daniel Picard
 Pasqualino de Antonellis
 Dong Anh Khuong-Quang
 Aline C. Planello
 Constanze Zeller
 Dalia Barsyte-Lovejoy
 Lucie Lafay-Cousin
 Louis Letourneau
 Mathieu Bourgey
 Man Yu
 Deena M.A. Gendoo
 Misko Dzamba
 Mark Barszczyk
 Tiago Medina
 Alexandra N. Riemenschneider
 A. Sorana Morrissy
 Young Shin Ra
 Vijay Ramaswamy
 Marc Remke
 Christopher P. Dunham
 Stephen Yip
 Ho keung Ng
 Jian Qiang Lu
 Vivek Mehta
 Steffen Albrecht
 Jose Pimentel
 Jennifer A. Chan
 Gino R. Somers
 Claudia C. Faria
 Lucia Roque
 Maryam Fouladi
 Lindsey M. Hoffman
 Andrew S. Moore
 Yin Wang
 Seung Ah Choi
 Jordan R. Hansford
 Daniel Catchpoole
 Diane K. Birks
 Nicholas K. Foreman
 Doug Strother
 Almos Klekner
 Laszló Bognár
 Miklós Garami
 Péter Hauser
 Tibor Hortobágyi
 Beverly Wilson
 Juliette Hukin
 Anne Sophie Carret
 Timothy E. Van Meter
 Eugene I. Hwang
 Amar Gajjar
 Shih Hwa Chiou
 Hideo Nakamura
 Helen Toledano
 Iris Fried
 Daniel Fults
 Takafumi Wataya
 Chris Fryer
 David D. Eisenstat
 Katrin Scheinemann
 Adam J. Fleming
 Donna L. Johnston
 Jean Michaud

Other Contributor(s)

University of Toronto
 Hospital for Sick Children University of Toronto
 Ontario Cancer Institute University of Toronto
 CHU de Lyon
 McGill University
 Alberta Children's Hospital
 University of Calgary
 Asan Medical Center
 The University of British Columbia
 Chinese University of Hong Kong
 University of Alberta
 Santa Maria Hospital, Lisbon
 Instituto Portugues de Oncologia de Francisco Gentil Lisboa
 Cincinnati Children's Hospital Medical Center
 University of Colorado School of Medicine
 University of Queensland
 Fudan University
 Seoul National University College of Medicine
 Royal Children's Hospital, Melbourne
 Children's Hospital At Westmead
 Debreceni Egyetem Altalanos Orvostudomanyi Kar
 Semmelweis Egyetem
 Szegedi Tudomanyegyetem (SZTE)
 University of Montreal
 Virginia Commonwealth University
 Childrens National Health System
 St. Jude Children's Research Hospital
 National Yang-Ming University Taiwan
 Kumamoto University
 Children's Medical Center of Israel
 Hadassah University Medical Centre
 University of Utah, School of Medicine
 Shizuoka Children's Hospital
 McMaster University, Faculty of Health Sciences
 Children's Hospital of Eastern Ontario, Ottawa
 London Health Sciences Centre
 Western University
 Dalhousie University
 Mahidol University
 University of Nottingham
 Ann & Robert H. Lurie Children's Hospital of Chicago
 University of California, San Francisco
 University of Alabama
 Julius-Maximilians-Universität Würzburg

Abstract

© 2016 Elsevier Inc. We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/42259

Collections

Scopus 2016-2017