Publication: A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from Western Thailand
Issued Date
2004-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-4544350026
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.35, No.2 (2004), 281-287
Suggested Citation
Chutima Kumkhaek, Kooruethai Phra-ek, Pratap Singhasivanon, Sornchai Looareesuwan, Chakrit Hirunpetcharat, Alan Brockman, Anne Charlotte Grüner, Nicolas Lebrun, Laurent Rénia, François Nosten, Georges Snounou, Srisin Khusmith A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from Western Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.35, No.2 (2004), 281-287. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21653
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Title
A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from Western Thailand
Abstract
Allelic variation in the Plasmodium falciparum circumsporozoite protein (CS) gene has been determined by sequencing the immunodominant T-cell epitopes, Th2R and Th3R, from 95 isolates from two malaria-endemic areas in the west of Thailand. Comparison with a reference sequence revealed only non-synonymous point mutations in the two epitope regions. Point mutations were found outside these epitopes in a minority of samples, and all but four were also non-synonymous. A relatively high number of variants, 11 Th2R and 9 Th3R, were detected and comprised some that had not been previously observed. However, the Th2R*05 and the Th3R*01 allelic variants predominated, as they were found in more than 70% of the 101 sequences obtained.
