Publication: Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
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Issued Date
2021-12-01
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ISSN
20452322
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2-s2.0-85118679477
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Mahidol University
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SCOPUS
Bibliographic Citation
Scientific Reports. Vol.11, No.1 (2021)
Suggested Citation
Sakkarin Bhubhanil, Chanon Talodthaisong, Mattaka Khongkow, Katawut Namdee, Prapimpun Wongchitrat, Werayut Yingmema, James A. Hutchison, Sarawut Lapmanee, Sirinan Kulchat Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels. Scientific Reports. Vol.11, No.1 (2021). doi:10.1038/s41598-021-01262-x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/79201
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Title
Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
Abstract
Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. We show that the curcumin-bound silver nanoparticles themselves exhibit low cytotoxicity and enhance proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. We then show that the hydrogel-nanoparticle composite promotes wound healing in in vivo studies on rats, accelerating wound closure by > 40% and reducing bacterial counts by 60% compared to commercial antibacterial gels. Histopathology indicates that the hydrogel composite enhances transition from the inflammation to proliferation stage of healing, promoting the formation of fibroblasts and new blood vessels, while target gene expression studies confirm that the accelerated tissue remodeling occurs along the normal pathways. As such these hydrogel composites show great promise as wound dressing materials with high antibacterial capacity.