Publication: Mast cell activation in the skin of Plasmodium falciparum malaria patients.
Accepted Date
2015-01-16
Issued Date
2015-02-07
Copyright Date
2015
Resource Type
Language
eng
ISSN
1475-2875 (electronic)
Rights Holder(s)
BioMed Central
Bibliographic Citation
Wilainam P, Nintasen R, Viriyavejakul P. Mast cell activation in the skin of Plasmodium falciparum malaria patients. Malar J. 2015 Feb 7;14(1):67.
Suggested Citation
Panop Wilainam, ภานพ วิไลนาม, Rungrat Nintasen, Parnpen Viriyavejakul, พรรณเพ็ญ วิริยเวชกุล Mast cell activation in the skin of Plasmodium falciparum malaria patients.. Wilainam P, Nintasen R, Viriyavejakul P. Mast cell activation in the skin of Plasmodium falciparum malaria patients. Malar J. 2015 Feb 7;14(1):67.. doi:10.1186/s12936-015-0568-8. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/804
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Mast cell activation in the skin of Plasmodium falciparum malaria patients.
Corresponding Author(s)
Abstract
BACKGROUND: Mast cells (MCs) play an important role in the immune response and
inflammatory processes. Generally, MCs can be stimulated to degranulate and
release histamine upon binding to immunoglobulin E (IgE). In malaria, MCs have
been linked to immunoglobulin (Ig) E-anti-malarial antibodies. This study
investigated the response of MCs in the skin of patients with Plasmodium
falciparum malaria.
METHODS: Skin tissue samples were examined from ten uncomplicated and 20
complicated P. falciparum malaria cases. Normal skin tissues from 29 cases served
as controls. Pre- and post-treatment tissues were included. Histopathological
changes of the skin were evaluated using haematoxylin and eosin stain. MCs were
investigated using toluidine blue staining. The percentage of MC degranulation
was compared among groups and correlated with clinical data.
RESULTS: MC degranulation was significantly higher in the complicated P.
falciparum (43.72% ± 1.44) group than the uncomplicated P. falciparum
(31.35% ± 3.29) (p <0.05) and control groups (18.38% ± 1.75), (p <0.0001). MC
degranulation correlated significantly with the degree of parasitaemia (r s
= 0.66, p <0.0001). Associated pathological features, including extravasation of
red blood cells, perivascular oedema and leukocyte infiltration were
significantly increased in the malaria groups compared with the control group
(all p <0.001).
CONCLUSIONS: MCs in the skin dermis are activated during malaria infection, and
the degree of MC degranulation correlates with parasitaemia and disease severity.