Publication: IgA nephropathy associated with Hodgkin's disease in children: A case report, literature review and urinary proteome analysis
Issued Date
2007-04-01
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ISSN
0931041X
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2-s2.0-33847378524
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Mahidol University
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SCOPUS
Bibliographic Citation
Pediatric Nephrology. Vol.22, No.4 (2007), 541-546
Suggested Citation
Sookkasem Khositseth, Nonglak Kanitsap, Naree Warnnissorn, Visith Thongboonkerd IgA nephropathy associated with Hodgkin's disease in children: A case report, literature review and urinary proteome analysis. Pediatric Nephrology. Vol.22, No.4 (2007), 541-546. doi:10.1007/s00467-006-0382-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24933
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Title
IgA nephropathy associated with Hodgkin's disease in children: A case report, literature review and urinary proteome analysis
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Abstract
We report herein a rare case of IgAN associated with Hodgkin's disease in a 14-year-old boy. Clinical manifestations and laboratory parameters were improved after treatment with CHOP chemotherapy and enalapril. Urinary proteins were isolated and examined using state-of-the-art proteomic technology, before and during the treatment course. Two-dimensional gel electrophoresis showed obvious alterations in the urinary proteome profile in response to such therapy. Quantitative intensity analysis and gel mapping revealed 14 altered proteins with reduced excretion levels during the treatment course, including albumin, albumin complexed with decanoic acid, α-1 antitrypsin, cadherin-11 precursor, collagen α 1 (VI) chain precursor, complement C1q tumor necrosis factor-related protein, Ig heavy chain, Ig light chain, kininogen, inter-β-trypsin inhibitor (α-1 microglobulin), inter-β-trypsin inhibitor heavy chain, leucine-rich α-2 glycoprotein, α-2 microglobulin, and transferrin precursor. Their potential roles in the pathogenesis and pathophysiology of IgAN are discussed. © IPNA 2006.