Publication: Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin
Issued Date
2012-08-10
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ISSN
14390221
00320943
00320943
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2-s2.0-84867850747
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.78, No.15 (2012), 1626-1632
Suggested Citation
Warisara Parichatikanond, Darawan Pinthong, Supachoke Mangmool Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin. Planta Medica. Vol.78, No.15 (2012), 1626-1632. doi:10.1055/s-0032-1315198 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13639
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Title
Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin
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Abstract
Overactivation of the renin-angiotensin system is one of the most important risk factors for the development of hypertension. The use of the crude extracts and/or active compounds, such as anthocyanins and quercetin, of herbal plants that have antihypertensive effects is beneficial for decreasing of blood pressure level. However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood. In this study, we demonstrate that delphinidin, cyanin, and quercetin interrupt the renin-angiotensin system signaling pathway by inhibiting the angiotensin-converting enzyme activity and decreasing its mRNA production. Furthermore, treatment with either delphinidin or cyanin significantly inhibited renin mRNA production. However, delphinidin, cyanin, and quercetin did not act as the angiotensin II type 1 receptor antagonist and did not play roles in the regulation of its internalization. The direct inhibition of components of the renin-angiotensin system advances our understanding of the antihypertensive effects of these compounds. © Georg Thieme Verlag KG Stuttgart New York.