Publication: Serum leptin concentrations in chronic hepatitis
Issued Date
2006-04-01
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ISSN
01252208
01252208
01252208
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2-s2.0-33646405181
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.89, No.4 (2006), 490-499
Suggested Citation
Rungsunn Tungtrongchitr, Sombat Treeprasertsuk, Nyein Ei Nyein, Apanchanid Thepouyporn, Benjaluck Phonrat, Arun Huntrup Serum leptin concentrations in chronic hepatitis. Journal of the Medical Association of Thailand. Vol.89, No.4 (2006), 490-499. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23775
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Title
Serum leptin concentrations in chronic hepatitis
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Abstract
The objectives of this research were to investigate the leptin levels among Chronic Hepatitis B Virus (HBV), Chronic Hepatitis C Virus (HCV) and non-alcoholic steatosis hepatitis (NASH) diseases of Thai patients compared with controls. Twenty of each HBV, HCV and NASH patients compared with sixty people as the control group from the Outpatient Department at the Hospital for Tropical Diseases, Bangkok, Thailand were investigated. Fasting blood samples were collected for investigation of leptin concentration, liver enzyme function tests and hematological variables. The serum leptin concentration of liver patients was significantly higher than that of control subjects. It might be due to the accumulations of fat cells in liver disease patients. However, there is no relationship between leptin level and other parameters such as BMI, ALT, AST, ALP and hematological variables. Liver enzyme functions levels are much higher in patients groups. White blood cells counts, platelets and hematocrit values are slightly lower in liver disease patients. Therefore, it is concluded that physiological regulation of leptin maintains in relation to body fat, even in chronic viral liver diseases. This finding and the apparent stage suggest the possibility that in the course of chronic viral diseases, serum leptin levels may reflect the extent of liver dysfunction.