Publication:
PRactice of VENTilation in Middle-Income Countries (PRoVENT-iMIC): Rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia

Issued Date

2018-04-01

Resource Type

Article

ISSN

20446055

DOI

10.1136/bmjopen-2017-020841

Other identifier(s)

2-s2.0-85057037600

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

BMJ Open. Vol.8, No.4 (2018)

Suggested Citation

Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Areef Ahsan, Abigail Beane, Kaweesak Chittawatanarat, Abul Faiz, Rashan Haniffa, Reza Hashemian, Madiha Hashmi, Hisham Ahmed Imad, Kanishka Indraratna, Shivakumar Iyer, Gyan Kayastha, Bhuvana Krishna, Hassan Moosa, Behzad Nadjm, Rajyabardhan Pattnaik, Sriram Sampath, Louise Thwaites, Ni Ni Tun, Nor'Azim Mohd Yunos, Salvatore Grasso, Frederique Paulus, Marcelo Gama De Abreu, Paolo Pelosi, Arjen M. Dondorp, Marcus J. Schultz PRactice of VENTilation in Middle-Income Countries (PRoVENT-iMIC): Rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia. BMJ Open. Vol.8, No.4 (2018). doi:10.1136/bmjopen-2017-020841 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46819

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

PRactice of VENTilation in Middle-Income Countries (PRoVENT-iMIC): Rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia

Author(s)

Luigi Pisani
 Anna Geke Algera
 Ary Serpa Neto
 Areef Ahsan
 Abigail Beane
 Kaweesak Chittawatanarat
 Abul Faiz
 Rashan Haniffa
 Reza Hashemian
 Madiha Hashmi
 Hisham Ahmed Imad
 Kanishka Indraratna
 Shivakumar Iyer
 Gyan Kayastha
 Bhuvana Krishna
 Hassan Moosa
 Behzad Nadjm
 Rajyabardhan Pattnaik
 Sriram Sampath
 Louise Thwaites
 Ni Ni Tun
 Nor'Azim Mohd Yunos
 Salvatore Grasso
 Frederique Paulus
 Marcelo Gama De Abreu
 Paolo Pelosi
 Arjen M. Dondorp
 Marcus J. Schultz

Other Contributor(s)

Ospedale Policlinico San Martino
 Bharati Vidyapeeth Medical College, Pune
 Sri Jayewardenepura General Hospital
 Ispat General Hospital
 The Aga Khan University
 Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders
 Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
 Università degli Studi di Bari
 Monash University Malaysia
 Hospital Israelita Albert Einstein
 Mahidol University
 National Research Institute of Tuberculosis and Lung Disease Tehran
 St. John's Medical College
 Amsterdam UMC - University of Amsterdam
 Chiang Mai University
 Oxford University Clinical Research Unit
 Medical Action Myanmar
 Dev Care Foundation
 Patan Academy of Health Sciences
 Indira Gandhi Memorial Hospital
 Oxford University Clinical Research Unit

Abstract

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Current evidence on epidemiology and outcomes of invasively mechanically ventilated intensive care unit (ICU) patients is predominantly gathered in resource-rich settings. Patient casemix and patterns of critical illnesses, and probably also ventilation practices are likely to be different in resource-limited settings. We aim to investigate the epidemiological characteristics, ventilation practices and clinical outcomes of patients receiving mechanical ventilation in ICUs in Asia. Methods and analysis PRoVENT-iMIC (study of PRactice of VENTilation in Middle-Income Countries) is an international multicentre observational study to be undertaken in approximately 60 ICUs in 11 Asian countries. Consecutive patients aged 18 years or older who are receiving invasive ventilation in participating ICUs during a predefined 28-day period are to be enrolled, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cm H 2 O) during the first 3 days of mechanical ventilation - compared between patients at no risk for acute respiratory distress syndrome (ARDS), patients at risk for ARDS and in patients with ARDS (in case the diagnosis of ARDS can be made on admission). Secondary outcomes include occurrence of pulmonary complications and all-cause ICU mortality. Ethics and dissemination PRoVENT-iMIC will be the first international study that prospectively assesses ventilation practices, outcomes and epidemiology of invasively ventilated patients in ICUs in Asia. The results of this large study, to be disseminated through conference presentations and publications in international peer-reviewed journals, are of ultimate importance when designing trials of invasive ventilation in resource-limited ICUs. Access to source data will be made available through national or international anonymised datasets on request and after agreement of the PRoVENT-iMIC steering committee. Trial registration number NCT03188770; Pre-results.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/46819

Collections

Scopus 2018