Publication: Tipranavir resistance associated mutations in protease inhibitor-naïve patients with HIV-1 subtype A/E infection
Issued Date
2008-11-01
Resource Type
ISSN
13866532
Other identifier(s)
2-s2.0-53649091416
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Virology. Vol.43, No.3 (2008), 284-286
Suggested Citation
Somnuek Sungkanuparph, Chonlaphat Sukasem, Weerawat Manosuthi, Surasak Wiboonchutikul, Bucha Piyavong, Wasun Chantratita Tipranavir resistance associated mutations in protease inhibitor-naïve patients with HIV-1 subtype A/E infection. Journal of Clinical Virology. Vol.43, No.3 (2008), 284-286. doi:10.1016/j.jcv.2008.07.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19282
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Tipranavir resistance associated mutations in protease inhibitor-naïve patients with HIV-1 subtype A/E infection
Other Contributor(s)
Abstract
Background: Tipranavir-resistance associated mutations (TPV-RAMs) are often observed among patients with HIV-1 subtype A/E infection. Data regarding TPV resistance in subtype A/E is still limited. Objectives: To determine the prevalence of TPV-RAMs among protease inhibitor-naïve, HIV-1 subtype A/E infected patients. Study design: Genotypic resistance testing was conducted among HIV-1-infected patients who were PI-naïve. Results: We studied 112 patients (mean age, 40.7 years; 58% male). Median CD4 cell count and HIV-1 RNA were 192 cells/mm3and 4.2 log copies/mL, respectively. Ninety-three patients (83%) infected with subtype A/E; the others had subtype B. The most common TPV-RAMs were M36I (88%), H69K (61%), and I13V (48%). Median number of TPV-RAMs was 3 mutations. Patients with subtype A/E had higher prevalence of I13V (54% vs. 21%, P = 0.011), M36I (96% vs. 53%, P < 0.001), H69K (68% vs. 26%, P = 0.001), and >2 TPV-RAMs (62% vs. 21%, P = 0.002). In multivariate analysis, only subtype A/E was associated with the occurrence of >2 TPV-RAMs (OR 9.83; 95%CI, 1.95-39.57; P = 0.006). Conclusions: TPV-RAMs previously described by IAS-USA are commonly observed in PI-naïve patients with HIV-1 subtype A/E infection. Further studies to define virologic response of subtype A/E to TPV and clinical validation of TPV-RAMs in HIV-1 subtype A/E are essentially needed. © 2008 Elsevier B.V. All rights reserved.