Publication: Synthesis and cytotoxic activity of 14-deoxy-12-hydroxyandrographolide analogs
Issued Date
2017-08-01
Resource Type
ISSN
15548120
10542523
10542523
Other identifier(s)
2-s2.0-85016510116
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Medicinal Chemistry Research. Vol.26, No.8 (2017), 1653-1663
Suggested Citation
Uthaiwan Sirion, Teerapich Kasemsuk, Pawinee Piyachaturawat, Kanoknetr Suksen, Apichart Suksamrarn, Rungnapha Saeeng Synthesis and cytotoxic activity of 14-deoxy-12-hydroxyandrographolide analogs. Medicinal Chemistry Research. Vol.26, No.8 (2017), 1653-1663. doi:10.1007/s00044-017-1881-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42206
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Synthesis and cytotoxic activity of 14-deoxy-12-hydroxyandrographolide analogs
Other Contributor(s)
Abstract
© 2017, Springer Science+Business Media New York. Abstract: Important anticancer cytotoxicological properties are reported from synthetic analogs of 14-deoxy-12-hydroxy-andrographolide, a compound that occurs in Andrographis paniculata, an indigenous Southeast Asia plant. Cytotoxicities of 15 synthesized 14-deoxy-12-hydroxy-andrographolide analogs were evaluated against a panel of cancer cell lines with some exhibiting much greater than the parent compound. For example analog 2j was 6–35 times more potent than the parent compound and the anticancer agent, ellipticin, on all cell lines except LU-1 cancer cells. With promising cytotoxicities and simple preparation, this compound has significant potential in the treatment of cancer. Graphical Abstract: [InlineMediaObject not available: see fulltext.].