Publication: The Dai minority population of Southwest China: Heterogeneity of DR2-associated HLA-DRB1,DRB5,DQA1, and DQB1 haplotypes
Issued Date
1996-01-01
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ISSN
01988859
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2-s2.0-0029924509
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Mahidol University
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SCOPUS
Bibliographic Citation
Human Immunology. Vol.45, No.2 (1996), 143-147
Suggested Citation
Li An Fan, Dasnayanee Chandanayingyong, Anajane G. Smith, John A. Hansen The Dai minority population of Southwest China: Heterogeneity of DR2-associated HLA-DRB1,DRB5,DQA1, and DQB1 haplotypes. Human Immunology. Vol.45, No.2 (1996), 143-147. doi:10.1016/0198-8859(95)00149-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17643
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Title
The Dai minority population of Southwest China: Heterogeneity of DR2-associated HLA-DRB1,DRB5,DQA1, and DQB1 haplotypes
Abstract
HLA-DR2 is the most common DR specificity (60.3%) identified in the Dai minority population of Xishuangbanna, Yunna Province, China. We characterized the DRB1, DRB5, DQA1, and DQB1 alleles of 44 unrelated DR2-positive individuals, 11 of whom (15%) were DR2 homozygous. Four DRB1 and four DRB5 alleles encoding DR2 were identified in this population. The most frequent DR2-associated DRB1 alleles were *1602 (gf = 0.164) and *1502 (gf = 0.151). DRB1*1501 (gf = 0.048) and a new allele designated DRB1*1504 (gf = 0.014) were also detected, but *1601 and *1503 were absent. The most frequent DR2-associated DRB5 alleles were *0101 (gf = 0.233) and *0102 (gf = 0.110). Nine different DR2-associated DR/DQ haplotypes were identified. The two most common DR2 haplotypes were DRB1*1602,DRB5*0101,DQA1*0102,DQB1*0502 (hf = 0.142) and DRB1*1502,DRB5*0102,DQA1*0101, DQB1*0501 (hf = 0.075). The new DRB1*1504 allele was found on a single haplotype: DRB1*1504, DRB5*0101,DQA1*0102,DQB1*0502 (hf = 0.017). The Dw2, Dw12, Dw21, and Dw22 haplotypes, present in many other Asian and Mongoloid populations, were not identified in this unique group. However, the Dai minority population is characterized by a relatively large number of diverse DR2 haplotypes and a new DRB1 allele encoding DR2.