International Journal for Vitamin and Nutrition Research. Vol.45, No.2 (1975), 113-123
Suggested Citation
W. Supopark, J. A. Olson Effect of ovral, a combination type oral contraceptive agent, on vitamin A metabolism in rats. International Journal for Vitamin and Nutrition Research. Vol.45, No.2 (1975), 113-123. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10801
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effect of ovral, a combination type oral contraceptive agent, on vitamin A metabolism in rats
When a typical combination type oral contraceptive agent (ovral, which contains 0.5 mg norgestrel and 0.05 mg ethinyl estradiol per tablet), is given to young female rats at 50 x the human dosage for an extended period, plasma vitamin A levels are elevated about 50%. The increase is mainly due to a higher steadystate level of retinol binding protein, and not to the presence of more lipoprotein bound retinyl ester. In Ovral treated rats, the depletion of vitamin A from the liver, calculated as a linear rate, as a linear rate per unit body weight, or as a half life, tends to be greater, although the differences are only marginally significant. The absorption, storage and short term excretion patterns of a dose of radioactive vitamin A are not demonstrably affected by Ovral treatment.
