Publication: Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia.
Issued Date
2015-01
Copyright Date
2014
Resource Type
Language
eng
ISSN
1360-2276 (printed)
1365-3156 (electronic)
1365-3156 (electronic)
Rights
Mahidol University
Rights Holder(s)
Blackwell Publishing
Bibliographic Citation
Emary KR, Carter MJ, Pol S, Sona S, Kumar V, Day NP. et al. Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia. Trop Med Int Health. 2015 Jan;20(1):24-8.
Suggested Citation
Emary, Katherine R. W., Carter, Michael J., Pol, Sreymom, Sona, Soeng, Kumar, Varun, Day, Nicholas P.J., Parry, Christopher M., Moore, Catrin E. Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia.. Emary KR, Carter MJ, Pol S, Sona S, Kumar V, Day NP. et al. Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia. Trop Med Int Health. 2015 Jan;20(1):24-8.. doi:10.1111/tmi.12398. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/795
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Thesis
Title
Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia.
Corresponding Author(s)
Abstract
OBJECTIVE: Antibiotic resistance is a prominent public and global health concern.
We investigated antibiotic use in children by determining the proportion of
unselected children with antibacterial activity in their urine attending a
paediatric outpatient department in Siem Reap, Cambodia.
METHODS: Caregiver reports of medication history and presence of possible
infection symptoms were collected in addition to urine samples. Urine antibiotic
activity was estimated by exposing bacteria to urine specimens, including
assessment against multiresistant bacteria previously isolated from patients in
the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a
multiresistant Salmonella typhi and an extended-spectrum β-lactamase
(ESBL)-producing Escherichia coli isolate).
RESULTS: Medication information and urine were collected from 775 children.
Caregivers reported medication use in 69.0% of children in the preceding 48 h.
31.7% samples showed antibacterial activity; 16.3% showed activity against a
local multiresistant organism. No specimens demonstrated activity against an
ESBL-producing E. coli.
CONCLUSIONS: Antibiotics are widely used in the community setting in Cambodia.
Parents are often ill-informed about drugs given to treat their children.
Increasing the regulation and training of private pharmacies in Cambodia may be
necessary. Regional surveillance of antibiotic use and resistance is also
essential in devising preventive strategies against further development of
antibiotic resistance, which would have both local and global consequences.