Publication: Manganese-Promoted Regioselective Direct C3-Phosphinoylation of 2-Pyridones
Issued Date
2021-06-07
Resource Type
ISSN
10990690
1434193X
1434193X
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2-s2.0-85110470805
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Organic Chemistry. Vol.2021, No.21 (2021), 3071-3078
Suggested Citation
Tanakorn Kittikool, Kunita Phakdeeyothin, Teera Chantarojsiri, Sirilata Yotphan Manganese-Promoted Regioselective Direct C3-Phosphinoylation of 2-Pyridones. European Journal of Organic Chemistry. Vol.2021, No.21 (2021), 3071-3078. doi:10.1002/ejoc.202100336 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76605
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Title
Manganese-Promoted Regioselective Direct C3-Phosphinoylation of 2-Pyridones
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Abstract
A highly efficient and regioselective manganese-induced radical oxidative direct C−P bond formation between 2-pyridones and secondary phosphine oxides was developed. The C3-selective phosphinoylation was conveniently achieved through a combination of substoichiometric manganese and persulfate oxidant under mild conditions. Various 3-phosphinoylated pyridone products can be obtained in moderate to high yields. Preliminary mechanistic studies suggest that the reaction is likely to involve a radical pathway induced by catalytically active Mn3+ species.