Publication: Predictors of postherpetic neuralgia in patients with herpes zoster: A pooled analysis of prospective cohort studies from North and Latin America and Asia
Issued Date
2015-05-01
Resource Type
ISSN
18783511
12019712
12019712
Other identifier(s)
2-s2.0-84928236416
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases. Vol.34, (2015), 126-131
Suggested Citation
Kosuke Kawai, Emmanouil Rampakakis, Tsen Fang Tsai, Hee Jin Cheong, Jittima Dhitavat, Alejandro Ortiz Covarrubias, Lin Yang, Miguel Cashat-Cruz, Homero Monsanto, Kelly Johnson, John S. Sampalis, Camilo J. Acosta Predictors of postherpetic neuralgia in patients with herpes zoster: A pooled analysis of prospective cohort studies from North and Latin America and Asia. International Journal of Infectious Diseases. Vol.34, (2015), 126-131. doi:10.1016/j.ijid.2015.03.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36458
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Title
Predictors of postherpetic neuralgia in patients with herpes zoster: A pooled analysis of prospective cohort studies from North and Latin America and Asia
Abstract
© 2015. Objectives: The most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality of life (QoL). This analysis aimed to evaluate predictors of PHN in HZ patients. Methods: A pooled analysis of prospective cohort studies of HZ patients aged ≥50 years from North America (Canada), Latin America (Brazil, Mexico, and Argentina), and Asia (Taiwan, South Korea, and Thailand) was performed. Patients within 14 days of rash onset were included. The incidence of PHN was defined as a worst pain score of ≥3, persisting/appearing at >90 days after rash onset. Socio-demographics, HZ disease characteristics, treatment, pain-related interference with activities of daily living, and health-related QoL were assessed. Results: Of 702 patients with HZ, 148 (21.1%) developed PHN. Similar risks of PHN were observed across geographic regions. On multivariate analysis, older age, greater severity of pain at rash onset, employment status, walking problems at enrollment, and pain interference affecting social relationships were significantly associated with the development of PHN. Conclusions: In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia.