Publication: Radical scavenging and antioxidnt activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.
Issued Date
2011-01-28
Resource Type
ISSN
15206025
01633864
01633864
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2-s2.0-79951548291
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.74, No.1 (2011), 79-81
Suggested Citation
Kamolchanok Tianpanich, Surasak Prachya, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Radical scavenging and antioxidnt activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.. Journal of Natural Products. Vol.74, No.1 (2011), 79-81. doi:10.1021/np1003752 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11602
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Title
Radical scavenging and antioxidnt activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.
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Abstract
Five known isocoumarins, monocerin (1), derivative 2, and fusarentin derivatives 3-5, and a new phthalide (6) were isolated from the endophytic fungus Colletotrichum sp. 2 selectively exhibited cytotoxic activity toward the HepG2 cell line. Compounds 2 and 4 scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals (IC50 values of 23.4 and 16.4 μM, respectively) and inhibited superoxide anion radical formation (IC50 values of 52.6 and 4.3 μM, respectively). The C-7 hydroxyl group in 2 and 4 might be important for radical scavenging activities. Isocoumarins 1-3 and phthalide 6 showed p otent antioxidant activity. © 2011 American Chemical Society and American Society of Pharmacognosy.