Publication: Recommended dose of alfacacidol for osteoporosis
Issued Date
2011-10-01
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ISSN
01252208
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2-s2.0-84858033850
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.94, No.10 SUPPL. (2011)
Suggested Citation
Narong Bunyaratavej Recommended dose of alfacacidol for osteoporosis. Journal of the Medical Association of Thailand. Vol.94, No.10 SUPPL. (2011). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12271
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Title
Recommended dose of alfacacidol for osteoporosis
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Abstract
The present study aims to investigate a proper dose of alfacalcidol by using the parathyroid level as a marker due to the end product of alfacalcidol is calcitriol which has a property of suppression secretion of parathyroid glands. The research enrolled 259 volunteers which were divided into 2 groups. Each group took the elemental calcium 800 milligram plus alfacalcidol at the different doses. Group (A) received alfacalcidol 1.0 microgram/day and Group (B) had alfacalcidol 1.5 micrograms/day for 3 months. Group (A) could not suppress the secretion of PTH compared with Group (B) of which the PTH level was decreased significantly (p = 0.047). Alfacalcidol in both groups can not decrease the bone resorption monitored by using the bone resorption marker, BetacrossLaps or bCTx.