Publication:
First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines

Issued Date

1985-01-01

Resource Type

Article

ISSN

00652571

DOI

10.1016/0065-2571(85)90091-3

Other identifier(s)

2-s2.0-0022193658

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Advances in Enzyme Regulation. Vol.24, No.C (1985), 429-434

Suggested Citation

J. Pausch, A. Holstege, T. Anukarahanonta, D. Keppler, W. Gerok First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines. Advances in Enzyme Regulation. Vol.24, No.C (1985), 429-434. doi:10.1016/0065-2571(85)90091-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30755

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Title

First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines

Author(s)

J. Pausch
 A. Holstege
 T. Anukarahanonta
 D. Keppler
 W. Gerok

Other Contributor(s)

Universitat Freiburg im Breisgau
 Mahidol University

Abstract

Sixteen unselected patients with non-resectable hepatocellular carcinoma were treated in a phase I study with 261 cycles of d-galactosamine and 6-azauridine prior to 5-fluorouridine. Thirty % of the patients survived for more than one year without signs of tumor progression and with an unchanged performance status. The compatibility of this chemotherapeutical method was quite satisafactory. The only extrahepatic side effect was a leucopenia and/or thrombocytopenia which was reversible upon reduction of the 5-fluoroudine dose. The heterogeneity of the 16 patients treated to date does not allow a definite statistical evaluation of the reported clinical observations and results. A final decision about the clinical applicability of this concept of a selective chemotherapy of hepatocellular carcinomal requires further experience. © 1985.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/30755

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Scopus 1969-1990