Publication: Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro
Issued Date
2014-01-01
Resource Type
ISSN
10986596
00664804
00664804
Other identifier(s)
2-s2.0-84905373498
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.58, No.8 (2014), 4935-4937
Suggested Citation
Chanaki Amaratunga, Benoit Witkowski, Dalin Dek, Vorleak Try, Nimol Khim, Olivo Miotto, Didier Ménard, Rick M. Fairhurst Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro. Antimicrobial Agents and Chemotherapy. Vol.58, No.8 (2014), 4935-4937. doi:10.1128/AAC.03055-14 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34808
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Title
Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro
Abstract
Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early ring stage of parasite development and that a genetically admixed population contains subsets of parasites with normal or reduced ART sensitivity. Copyright © 2014, American Society for Microbiology. All Rights Reserved.