Publication: Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria
Issued Date
2002-04-09
Resource Type
ISSN
00664804
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2-s2.0-0036207484
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.46, No.4 (2002), 1125-1127
Suggested Citation
Paul N. Newton, Michele Van Vugt, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Maneerat Rasameesoroj, Pramote Teerapong, Ronatrai Ruangveerayuth, Thra Slight, Francois Nosten, Yupin Suputtamongkol, Sornchai Looareesuwan, Nicholas J. White Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria. Antimicrobial Agents and Chemotherapy. Vol.46, No.4 (2002), 1125-1127. doi:10.1128/AAC.46.4.1125-1127.2002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20503
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Title
Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria
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Abstract
Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated faiciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.