Publication: An epidemiological study of aplastic anaemia: Relationship of drug exposures to clinical features and outcome
Issued Date
1996-12-03
Resource Type
ISSN
09024506
Other identifier(s)
2-s2.0-0030344665
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Haematology, Supplement. Vol.57, No.60 (1996), 47-52
Suggested Citation
Judith Parsells Kelly, Jan M. Jurgelon, Surapol Issaragrisil, Marianne Keisu, David W. Kaufman An epidemiological study of aplastic anaemia: Relationship of drug exposures to clinical features and outcome. European Journal of Haematology, Supplement. Vol.57, No.60 (1996), 47-52. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17652
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
An epidemiological study of aplastic anaemia: Relationship of drug exposures to clinical features and outcome
Other Contributor(s)
Abstract
Two hypotheses were examined in the combined data from 3 case-control studies of aplastic anaemia, conducted in Thailand, Europe/ Israel and the US: 1. Cases exposed to drugs associated with a significantly increased risk of aplastic anaemia are more likely to present with thrombocytopenia (e.g. petechiae, easy bruising); and 2. cases exposed to these drugs are more likely to recover quickly than non-exposed cases. After excluding all cases who lacked information on timing of symptoms and those whose symptoms began ≤ 180 d before hospital admission, 392 cases remained for analysis. A total of 51 (13%) had been exposed to one of the significantly associated drugs; the remaining 341 (87%) had not. Among the former, 31% reported thrombocytopenia either before or at the same time as non-bleeding symptoms (e.g. pallor, fatigue); the corresponding proportion among the non-exposed was 53%. Data on time to recovery (return of the 3 blood cell lines to normal levels) were not available for the Thai cases; among the others, the median time to recovery for the non-fatal cases was 7 and 6 months in the 29 exposed and the 83 non-exposed cases, respectively The data do not support either hypothesis: the two groups of aplastic anaemia cases appeared to be similar in both the presenting symptoms and the recovery time.