Publication: New insights into the immunopathology and control of dengue virus infection
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Issued Date
2015-12-01
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ISSN
14741741
14741733
14741733
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2-s2.0-84948706705
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Reviews Immunology. Vol.15, No.12 (2015), 745-759
Suggested Citation
Gavin Screaton, Juthathip Mongkolsapaya, Sophie Yacoub, Catherine Roberts New insights into the immunopathology and control of dengue virus infection. Nature Reviews Immunology. Vol.15, No.12 (2015), 745-759. doi:10.1038/nri3916 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36036
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Title
New insights into the immunopathology and control of dengue virus infection
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Abstract
© 2015 Macmillan Publishers Limited. All rights reserved. Dengue virus poses a major threat to global public health: two-thirds of the world's population is now at risk from infection by this mosquito-borne virus. Dengue virus causes a range of diseases with a small proportion of infected patients developing severe plasma leakage that leads to dengue shock syndrome, organ impairment and bleeding. Infection with one of the four viral serotypes results in the development of homotypic immunity to that serotype. However, subsequent infection with a different serotype is associated with an increased risk of developing severe disease, which has led to the suggestion that severe disease is triggered by immunopathology. This Review outlines recent advances in the understanding of immunopathology, vaccine development and human monoclonal antibodies produced against dengue virus.