Publication: Serum transcobalamin II levels in patients with malaria infection.
Issued Date
1995-03-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0029258370
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.26, No.1 (1995), 46-50
Suggested Citation
S. Areekul, K. Churdchu, C. Cheeramakara, P. Wilairatana, P. Charoenlarp Serum transcobalamin II levels in patients with malaria infection.. The Southeast Asian journal of tropical medicine and public health. Vol.26, No.1 (1995), 46-50. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17434
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Serum transcobalamin II levels in patients with malaria infection.
Other Contributor(s)
Abstract
Serum transcobalamin II (TCII) levels were determined in 56 patients with P. falciparum malaria infection. They were divided into 3 groups: severe (malarial parasite > 5% or patients with cerebral malaria or renal insufficiency), moderate (1-5% infection without complications) and mild (1% infection). Elevated serum TCII values were found only in patients with severe malaria infection. These values correlated directly with parasitemia, blood urea nitrogen and creatinine, but were not correlated with alkaline phosphatase. As 17 patients with azotemia had elevated serum TCII levels while other 3 patients with normal BUN and creatinine concentrations had serum TCII levels within the normal limits. These findings indicated that malarial patients with renal insufficiency had increased serum TCII. A possible mechanism is the reduced TCII-B12 that filtered through the glomeruli due to the reduced renal blood flow with the decreased its uptake by proximal tubular cells resulting in the decreased degradation of TCII by the tubular lysosomal enzymes. Determination of serum TCII level may be used as an indicator of renal function in malarial patients with renal insufficiency.