Publication: Paraoxonase 1 (PON1) L55M and Q192R polymorphisms are associated with type 2 diabetes mellitus in Southern Thai subjects
Issued Date
2020-05-01
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01252208
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2-s2.0-85085987100
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.103, No.5 (2020), 472-480
Suggested Citation
N. Didas, W. Thitisopee, S. Porntadavity, M. Nuinoon, P. Bhoopong, N. Jeenduang Paraoxonase 1 (PON1) L55M and Q192R polymorphisms are associated with type 2 diabetes mellitus in Southern Thai subjects. Journal of the Medical Association of Thailand. Vol.103, No.5 (2020), 472-480. doi:10.35755/jmedassocthai.2020.05.11051 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58194
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Title
Paraoxonase 1 (PON1) L55M and Q192R polymorphisms are associated with type 2 diabetes mellitus in Southern Thai subjects
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Abstract
© JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND | 2020 Background: Paraoxonase 1 (PON1) plays a critical role in the prevention of cardiovascular disease, diabetes mellitus, and other chronic diseases. Objective: The aim of the present study was to investigate the association of PON1 L55M and Q192R polymorphisms with type 2 diabetes mellitus (T2DM), and pre-diabetes. Materials and Methods: The present study included 512 subjects (223 T2DM patients, 150 pre-diabetes, and 139 healthy controls) from Southern Thailand. The PON1 L55M and Q192R polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: PON1 Q192R polymorphism showed a statistical difference in genotype frequencies between T2DM patients and healthy controls (p<0.0001). Multiple logistic regression analyses after adjusting for age, gender, and BMI showed that LM and RR genotypes increased the risk for T2DM compared with LL and QQ+QR genotypes (OR 1.96; 95% CI 1.02 to 3.76, p=0.042, and OR 1.85; 95% CI 1.11 to 3.10, p=0.019, respectively). Whereas, QR, genotype was associated with decreased risk for T2DM (OR 0.240; 95% CI 0.13 to 0.45, p<0.0001), and pre-diabetes (OR 0.549; 95% CI 0.30 to 0.99, p=0.048) compared with QQ genotype. Conclusion: PON1 LM and RR genotypes may be genetic risk factors for developing T2DM but QR genotype may prevent T2DM, and pre-diabetes in Southern Thai population.