Publication: Rising leukemia rates in Thailand: The possible role of benzene and related compounds in cigarette smoke
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Issued Date
2002-11-01
Resource Type
ISSN
17912431
1021335X
1021335X
Other identifier(s)
2-s2.0-0036834329
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Oncology Reports. Vol.9, No.6 (2002), 1399-1403
Suggested Citation
Eugene J. Mitacek, Klaus D. Brunnemann, Anthony P. Polednak, Thira Limsila, Kris Bhothisuwan, Charles F. Hummel Rising leukemia rates in Thailand: The possible role of benzene and related compounds in cigarette smoke. Oncology Reports. Vol.9, No.6 (2002), 1399-1403. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20033
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Title
Rising leukemia rates in Thailand: The possible role of benzene and related compounds in cigarette smoke
Abstract
Epidemiological studies suggest that cigarette smoking is associated with an increased risk of leukemia and that benzene and related compounds in cigarette smoke may contribute to this elevated risk. This report presents new findings on selected components of cigarette smoke (including benzene and 1,3-butadiene) from major brands of cigarettes sold in Thailand, which represent about 80% of market share. Tested were also two major and popular brands of U.S. cigarettes sold in Thailand, representing about 10% of market share. The cigarettes tested were filter and non-filter, and with high and 'low' tar and nicotine levels. The observed range for benzene, toluene and 1,3-butadiene were found in the range of 25.5-63.7, 36.4-79.8 and 44.6-78.7 μg/cigarette, respectively. The amount of acrolein ranged from 79.9-181 μg/cigarette and for isoprene from 313-694 μg/cigarette. Yields of these substances showed no correlation with tar deliveries in mainstream smoke. Consumption of tobacco products increased in Thailand since 1970. This study also showed increases in leukemia mortality rates in Thailand, and in the relative frequency of leukemia among incident cancers diagnosed at a large hospital in Bangkok. Exposure to benzene and related compounds in cigarette smoke may have contributed to these trends. Analytic epidemiological studies are needed on the relationship between these compounds in smoke from tobacco products used in Thailand. These preliminary findings support the need for voluntary and/or government-regulated reduction in smoke yields of benzene and related compounds in tobacco products, and for expanded smoking prevention and cessation efforts, in Thailand.