Publication: Short- and long-term outcomes of children with cyclic vomiting syndrome
Issued Date
2014-01-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-84924292773
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.97, No.10 (2014), 1077-1083
Suggested Citation
Suporn Treepongkaruna, Chaowapong Jarasvaraparn, Pornthep Tanpowpong, Chatmanee Lertudomphonwanit Short- and long-term outcomes of children with cyclic vomiting syndrome. Journal of the Medical Association of Thailand. Vol.97, No.10 (2014), 1077-1083. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34469
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Title
Short- and long-term outcomes of children with cyclic vomiting syndrome
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Abstract
© 2014, Medical Association of Thailand. All rights reserved. Objective: To determine the efficacy of prophylactic pharmacotherapy on the short- and long-term outcomes of children with cyclic vomiting syndrome (CVS). Material and Method: Medical records were reviewed in 32 children who were diagnosed with CVS between 2000 and 2013. Efficacy of prophylactic medications was classified as good vs. no response after treatment for three to six months. Long-term outcome was evaluated in patients who had been diagnosed for ≥2 years and classified as 1) excellent: no episode, 2) good: one to two episodes, and 3) poor: three episodes or more during the past year. Results: At three to six months after treatment, good response to amitriptyline was significantly higher than propranolol (73% vs. 36%, p = 0.04). Of the 24 CVS patients who had been diagnosed ≥2 years, data was available in 19 patients (mean age, 11.3±4.9; and mean duration from diagnosis to follow-up, 6.3±3.3 years). Excellent outcome was achieved in seven, good in seven, and poor in five children. Overall, the favorable long-term outcome (good and excellent) was 74%. Most children (86%) who had favorable long-term outcome had good response to the prophylactic medications in the early period of treatment. Conclusion: Amitriptyline may be more effective than propranolol for prophylaxis of CVS. However, a randomized controlled trial is required to confirm this result. Children with CVS have a relatively favorable long-term outcome, particularly those who initially responded well to the prophylactic medications.