Publication: Differential stability of the mRNA secondary structures in the frameshift site of various HIV type 1 viruses
Issued Date
1999-11-20
Resource Type
ISSN
08892229
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2-s2.0-0033589709
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Mahidol University
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SCOPUS
Bibliographic Citation
AIDS Research and Human Retroviruses. Vol.15, No.17 (1999), 1591-1596
Suggested Citation
Sui Yuan Chang, Ruengpung Sutthent, Prasert Auewarakul, Chatchawann Apichartpiyakul, Max Essex, Tun Hou Lee Differential stability of the mRNA secondary structures in the frameshift site of various HIV type 1 viruses. AIDS Research and Human Retroviruses. Vol.15, No.17 (1999), 1591-1596. doi:10.1089/088922299309892 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25424
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Title
Differential stability of the mRNA secondary structures in the frameshift site of various HIV type 1 viruses
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Abstract
For many retroviruses, one or more ribosomal frameshift events are required for translation of the Gag-Pol precursor protein, which is subsequently processed into the structural and enzymatic proteins found in mature virions. A specific nucleotide motif, the slippery sequence, as well as a downstream mRNA secondary structure are generally believed to have roles in the frameshift event. In HIV-1, a particular stem-loop mRNA secondary structure has been proposed for subtype B. On the basis of this model, HIV-1 subtypes A, E, and F were found in this study to share a similar stem-loop structure predicted to have a lower thermodynamic stability as compared with HIV-1 subtypes B, C, and D. The potential impact of this differential thermodynamic stability on HIV-1 replication remains to be determined.