Publication: Comparison of erythrocyte antioxidative enzyme activities between two types of haemoglobin H disease
Issued Date
1986-01-01
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ISSN
00219746
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2-s2.0-0022889356
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Pathology. Vol.39, No.12 (1986), 1299-1303
Suggested Citation
S. Prasartkaew, A. Bunyaratvej, S. Fucharoen, P. Wasi Comparison of erythrocyte antioxidative enzyme activities between two types of haemoglobin H disease. Journal of Clinical Pathology. Vol.39, No.12 (1986), 1299-1303. doi:10.1136/jcp.39.12.1299 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9837
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Title
Comparison of erythrocyte antioxidative enzyme activities between two types of haemoglobin H disease
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Abstract
The activities of erythrocyte antioxidative enzymes were measured in two groups of patients with different genotypes of haemoglobin (Hb) H disease: 21 with α-thalassaemia or α-thalassaemia 2 (α-thalassaemia 1/2) and 21 with α-thalassaemia l/Hb Constant Spring (HbCS). They were compared with 21 normal subjects. Both genotypes of Hb H disease had increased activities of erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase when compared with those of controls. Comparison of the two genotypes showed that subjects with α-thalassaemia /Hb CS, the more severe disease, had higher SOD and GSH-Px activities but lower catalase activity than those with α-thalassaemia 1/2. This indicates that there are compensatory mechanisms in Hb H erythrocytes to cope with increased generation of oxygen free radicals as a result of increased excess ,β chain.
