Publication: Enhancing effects of dimethylnitrosamine on aflatoxin B<inf>1</inf> hepatocarcinogenesis in rats
Issued Date
1981-01-01
Resource Type
ISSN
10970215
00207136
00207136
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2-s2.0-0019415260
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Cancer. Vol.28, No.5 (1981), 621-626
Suggested Citation
Subhkij Angsubhakorn, Natth Bhamarapravati, Kanda Romruen, Somphong Sahaphong Enhancing effects of dimethylnitrosamine on aflatoxin B<inf>1</inf> hepatocarcinogenesis in rats. International Journal of Cancer. Vol.28, No.5 (1981), 621-626. doi:10.1002/ijc.2910280515 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30160
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Title
Enhancing effects of dimethylnitrosamine on aflatoxin B<inf>1</inf> hepatocarcinogenesis in rats
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Abstract
In a study of possible enhancing effects of dimethylnitrosamine (DMN) on aflatoxin B1 (AFB1) hepatocarcinogenesis, male Buffalo strain rats were fed diets containing 1 ppm AFB1, 25 ppm DMN, and a combination of 1 ppm AFB1 and 25 ppm DMN (AFB1 + DMN). The diets were replaced by chow pellets after 6 months, and animals were killed 3,6,9 and 12 months after the onset of the experiment. In the untreated control group animals were free of hepatocellular carcinoma but the treated groups fed AFB1, DMN and AFB1 plus DMN developed hepatic lesions ranging from multiple cysts, altered cell foci and neoplastic nodules to hepatocellular carcinomas. Hepatocellular carcinomas developed in 79%, 45% and 5% of rats fed AFB1 plus DMN, AFB1 and DMN respectively at the end of the experiment. Multiple cysts were also found in all periods in animals fed AFB1 plus DMN, whereas rats fed AFB1 and DMN separately developed a few multiple cysts by the end of the experiment. These findings suggest that DMN potentiates the hepatocarcinogenesis induced by AFB1 in rats. Copyright © 1981 Wiley‐Liss, Inc., A Wiley Company