Publication: Guidelines for antiretroviral therapy in HIV-1 infected adults and adolescents: The recommendations of the thai AIDS society (TAS) 2008
Issued Date
2008-12-01
Resource Type
ISSN
01252208
01252208
01252208
Other identifier(s)
2-s2.0-58949084547
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.91, No.12 (2008), 1925-1936
Suggested Citation
Somnuek Sungkanuparph, Thanomsak Anekthananon, Narin Hiransuthikul, Chureeratana Bowonwatanuwong, Khuanchai Supparatpinyo, Piroon Mootsikapun, Ploenchan Chetchotisakd, Sasisopin Kiertiburanakul, Somsit Tansuphaswadikul, Wanchai Buppanharun, Weerawat Manosuthi, Wichai Techasathit, Winai Ratanasuwan, Woraphot Tantisiriwat, Surapol Suwanagool, Manoon Leechawengwongs, Kiat Ruxrungtham Guidelines for antiretroviral therapy in HIV-1 infected adults and adolescents: The recommendations of the thai AIDS society (TAS) 2008. Journal of the Medical Association of Thailand. Vol.91, No.12 (2008), 1925-1936. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19462
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Title
Guidelines for antiretroviral therapy in HIV-1 infected adults and adolescents: The recommendations of the thai AIDS society (TAS) 2008
Author(s)
Somnuek Sungkanuparph
Thanomsak Anekthananon
Narin Hiransuthikul
Chureeratana Bowonwatanuwong
Khuanchai Supparatpinyo
Piroon Mootsikapun
Ploenchan Chetchotisakd
Sasisopin Kiertiburanakul
Somsit Tansuphaswadikul
Wanchai Buppanharun
Weerawat Manosuthi
Wichai Techasathit
Winai Ratanasuwan
Woraphot Tantisiriwat
Surapol Suwanagool
Manoon Leechawengwongs
Kiat Ruxrungtham
Thanomsak Anekthananon
Narin Hiransuthikul
Chureeratana Bowonwatanuwong
Khuanchai Supparatpinyo
Piroon Mootsikapun
Ploenchan Chetchotisakd
Sasisopin Kiertiburanakul
Somsit Tansuphaswadikul
Wanchai Buppanharun
Weerawat Manosuthi
Wichai Techasathit
Winai Ratanasuwan
Woraphot Tantisiriwat
Surapol Suwanagool
Manoon Leechawengwongs
Kiat Ruxrungtham
Abstract
Background: More than 100,000 patients have been treated, since the implementation of the National Universal Coverage for antiretroviral therapy (ART) in Thailand. Although there are several comprehensive guidelines available internationally, there is a need to have guidelines that can be implemented in Thailand. Material and Method: The guidelines were developed by a panel of 17 members who are the experts on HIV research and/or HIV patient care and appointed without incentive by the Thai AIDS Society (TAS). The recommendations were based on evidences from the published studies and availability of antiretroviral agents. Published studies that are relevant and applicable to Thailand in particular have been taken into consideration. Results: The recommendations include: when to start ART; what to start; how to monitor the therapy; adverse effects and its management; diagnosis of treatment failure; and antiretroviral treatment options in patients with treatment failure. ART in special circumstances, i.e. patients with co-infection of tuberculosis or hepatitis B virus, is also included. Appropriate level of CD4+T-cell count to start ART among Thai patients has been considered carefully. The authors recommend to start ART at CD4+T-cell count < 200 cells/mm3. Conclusion: ART should be initiated in adults and adolescents HIV-1 infected patients with a history of HIV-related illness or AIDS or with a CD4+T-cell count < 200 cells/mm3. For treatment-naive patients, the preferred initial therapy is a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen. CD4+T-cell count and viral load should be monitored for at least twice and once a year, respectively. Proper management of antiretroviral-related toxicity and enhancement of adherence are crucial for the long-term success of ART.