Publication: Induction of apoptosis in densovirus infected Aedes aegypti mosquitoes
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Issued Date
2010-07-01
Resource Type
ISSN
10960805
00222011
00222011
Other identifier(s)
2-s2.0-77954862362
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Invertebrate Pathology. Vol.104, No.3 (2010), 239-241
Suggested Citation
Songsak Roekring, Duncan R. Smith Induction of apoptosis in densovirus infected Aedes aegypti mosquitoes. Journal of Invertebrate Pathology. Vol.104, No.3 (2010), 239-241. doi:10.1016/j.jip.2010.04.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28485
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Title
Induction of apoptosis in densovirus infected Aedes aegypti mosquitoes
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Abstract
The mechanism of death in densovirus infected mosquitoes remains unexplored. This study investigated the cellular consequences of densovirus infection in Aedes aegypti mosquitoes after a second generation challenge with a densovirus isolated from adult Aedes albopictus mosquitoes in Thailand (AThDNV). Specimens were analyzed by TUNEL assay, fluorescent in situ hybridization (FISH) and a calorimic assay to detect activation of caspase 3-like activity. After challenge, moribund mosquitoes showed considerable evidence of TUNEL positive cells. The caspase 3-like activity assay showed that the presence of TUNEL positive cells was associated with increased levels of activated caspase 3-like activity in AThDNV infected mosquitoes. © 2010 Elsevier Inc.